Proliferative Citreoretinopathy (PVR)

Proliferative vitreoretinopathy (PVR) remains the major complication after retinal detachment surgery.

The experimental model of PVR in albino rabbits is based in the combination of some factors suspected of causing the disease in humans. In brief, intravitreal injection of 0.15ml of platelet-rich plasma (PRP), transconjuctival cryotherapy and vitrectomy are performed in the rabbits. PRP is prepared from fresh citrated rabbit blood.

In the porcine model of PVR platelet rich plasma contributed more effectively to the development of PVR than platelet-derived growth factor (PDGF). In brief, animals receive four retinectomies in the posterior retina, a partial mechanical vitectomy and six cryoapplications at the retinal periphery. In addition, platelet concentrated plasma is injected intravitreally.