Subretinal Injection Retinal Detachment
Tipo
In vivo
Zona
Posterior segment
Enfermedad objetivo

Age-related Macular Degeneration (AMD) Inherited Retinal Diseases Retinal Detachment

Especies

Mouse (Mus Musculus), Rat (Rattus norvegicus)

Descripción

Subretinal injection has been shown to be the most common and efficient way to deliver advanced therapies (such as cell and gene therapies) for photoreceptors and/or retinal pigment epithelium (RPE) pathologies. Furthermore, subretinal injections of different substances is an adequate method of inducing retinal detachment. In brief, a tunnel through the sclera and the choroid is created until the subretinal space, between the neural retina and the RPE, is reached. Then, substances are gently and slowly microinjected into the subretinal space with a microinjection system .

Referencias académicas
  • Fernandez-Bueno I, et al. Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene- glycol. Mol Vis 2019;25:194-205
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